dynamo.pp.lambda_correction
- dynamo.pp.lambda_correction(adata, lambda_key='lambda', inplace=True, copy=False)[source]
Use lambda (cell-wise detection rate) to estimate the labelled RNA.
- Parameters:
adata (
AnnData) – an adata object generated from dynast.lambda_key (
str) – the key to the cell-wise detection rate. Defaults to “lambda”.inplace (
bool) – whether to inplace update the layers. If False, new layers that append ‘_corrected” to the existing will be used to store the updated data. Defaults to True.copy (
bool) – whether to copy the adata object or update adata object inplace. Defaults to False.
- Raises:
ValueError – the lambda_key cannot be found in adata.obs
ValueError – data_type is set to ‘splicing_labeling’ but the existing layers in the adata object don’t meet the requirements.
ValueError – data_type is set to ‘labeling’ but the existing layers in the adata object don’t meet the requirements.
- Return type:
- Returns:
A new AnnData object that are updated with lambda corrected layers if copy is true. Otherwise, return None.